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2.11d: Riboflavin
and Thiamine
Update 29 Nov. 2021. Riboflavin,
or Vitamin B2
Riboflavin, or Vitamin B2, is involved in oxidation-reduction and assists anti-oxidants.
Riboflavin
food source: egg, lean meat, broccoli, enriched bread and cereal. In USA, food staples are
fortified with riboflavin.
Human
experiment using riboflavin-lacking diet or riboflavin antagonist showed
deficiency syndrome of sore throat, inflamed, reddened tongue, mouth-ulcer, and lip corner fissure, seborrheic dermatitis (dandruff scalp and scaly May skin), and
red blood cell anemia of normal size and color cells. Riboflavin
deficiency is seen only in severely malnourished person and associated with
other deficiencies of B-complex (Thiamine B1, Niacin B3,
pyridoxine B6, folic acid and cobalamin B12).
Riboflavin deficiency
from genetic inborn error can be diagnosed by pediatrician
shortly after birth, and is helped by high dose of riboflavin daily. It is seen in
infants also as part of the deadly Reye's syndrome from aspirin treatment of virus-caused fever
and is partly treated with riboflavin.
Megavitamin riboflavin has been tried much with no success.
Megavitamin riboflavin has been tried much with no success.
Thiamine or
Vitamin B1
Thiamin(e) (Vitamin B1) in vitamin pill is the hydrochloride
(Th-HCl). Its food source is yeast, pork, and bean. In cereal grain (rice, wheat),
thiamine is mostly located in the germ or brown husk and not in the much
larger, central body. (Hence, beriberi from eating only white rice!) Otherwise
it is not high in food, explaining why beriberi was widespread before vitamin
fortification.
Food
processing destroys thiamine, particularly prolonged cooking, canning,
and baking (but not freezing). Pasteurization and other food sterilization
destroy it; and, since it is water soluble, even rinsing fortified white rice
before cooking results in its loss. Staple foods in the U.S. are fortified so
Americans with good appetite do not need to worry about thiamine.
Alcohol lowers intestinal thiamine uptake; so, heavy alcohol drinker is at risk for the
deficiency.
Thiamine is closely involved in release of energy to tissue cell from oxidation of glucose and fatty acid. It is important in nerve conduction. Its deficiency syndrome is seen in beriberi, either heart failure with rapid heart rate and massive swelling (wet beriberi) or loss of nerve function and brain disease (dry beriberi) including memory loss. Early sign: rapid heart (≧100 beats/min) at rest, easy fatigue, and pin and needle feeling in hand and foot.
Thiamine is closely involved in release of energy to tissue cell from oxidation of glucose and fatty acid. It is important in nerve conduction. Its deficiency syndrome is seen in beriberi, either heart failure with rapid heart rate and massive swelling (wet beriberi) or loss of nerve function and brain disease (dry beriberi) including memory loss. Early sign: rapid heart (≧100 beats/min) at rest, easy fatigue, and pin and needle feeling in hand and foot.
Who is at
Risk? Alcoholic, homeless, prolonged fasting and breast-fed infant of deficient
mother.
Thiamine is very important in acute alcoholism. Adequate intake will prevent permanent damage and there is no upper limit to the intake.
There is no
easy blood test for thiamine.
Medicinal
& Megavitamin Use: Genetic
inborn error requires lifetime high-dose injected thiamine, it
shows severe symptom shortly after birth. Treatment of alcoholism requires
daily dose thiamine. The chronic alcoholic (or the non alcoholic with persistent vomiting) exhausts his body supply of thiamine in 7 or 8 weeks during which time glucose IV infusion may suddenly evoke a thiamine deficiency syndrome that could kill. So doctors give 100 mg or more of thiamine daily to alcoholics or other severely malnourished persons seen in emergency. High-dose daily thiamine is treatment of beriberi. Alcoholics should take daily thiamine supplement.
Megavitamin doses have been tried much for schizophrenia and manic depression, but no identifiable result.
Megavitamin doses have been tried much for schizophrenia and manic depression, but no identifiable result.
Chapter
Continues click 2.11e Everything you need to read on vitamin A
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